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KMID : 1007520150240031167
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Food Science and Biotechnology
2015 Volume.24 No. 3 p.1167 ~ p.1176
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Dermal Toxicity Study of Rice Bran Supercritical CO2 Extract in Sprague-Dawley Rats
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Choi Jae-Suk
Cheon Eun-Jin
Kim Tae-Uk
Moon Woi-Sook
Kim Joo-Wan
Kim Mi-Ryung
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Abstract
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The present study was carried out to evaluate the dermal toxicity of topically administered rice bran supercritical CO2 extract (RB-SCE; 500, 1,000, and 2,000 mg/kg) in male and female rats when given as a single dose and a 4-week repeated dose. In all rats that underwent the single-dose toxicity test, there were no abnormal changes in clinical signs or body weight and no deaths or abnormal gross necropsy findings related to RB-SCE. Based on the above results, the LD50 is >2,000 mg/kg in both sexes. In all rats that underwent the 4-week repeated dermal toxicity test, there were no abnormal RB-SCEassociated changes with respect to external signs, urine and blood, or organs. The no-observed-adverse-effect level (NOAEL) of RB-SCE was thus considered to be 2,000 mg/kg/day for both sexes and the target organ. RB-SCE can be regarded as a very safe agent for topical dermal administration at a moderate dose.
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KEYWORD
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rice bran, supercritical CO2 extract, noobserved-adverse-effect level, dermal toxicity, rat
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